Clifford Avenue is between Culver Road and North Goodman. You can take 590 N and exit at the Empire Blvd exit. You go left onto Empire Blvd, which turns into Clifford Avenue.
Below are directions from the 490 Expressway.
Merge onto I-490 E via exit 20A toward ROCHESTER
Merge onto INNER LOOP via exit number 13 on the left toward DOWNTOWN/ PLYMOUTH AVE.
Take the E. MAIN ST../UNIVERSITY AVE. exit--merging left.